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GDNF increases several enzymes that help prevent oxidative stress , including [15]: glutathione peroxidase (GPx) superoxide dismutase (SOD) catalase 4) Protects and Repairs Neurons Throughout the body, GDNF aids in nerve cell repair and survival [16, 17]

Moreover, mutations in the Zip7 gene have been linked to a novel autosomal recessive disease characterized by agammaglobulinemia and early-onset infections, highlighting the crucial role of Zip7 in B cell development and immune function, as confirmed through CRISPR-Cas9 mutagenesis in mice [44]

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In an in vivo AD model, reactive astrocytes were converted into neurons via the expression of miR-302/367 cluster